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DOI: 10.1016/j.bbih.2022.100494

Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia

Brain Behav Immun Health. 2022 Aug 4:24:100494. doi: 10.1016/j.bbih.2022.100494. PMID: 35965838.

Johannes Teller, Carolin Jung, Justus B H Wilke, Svea-Dorothée Schimmelpfennig, Martin Hindermann, Lukas Hinken, Maria M Gabriel, Christine Fegbeutel, Andreas Schäfer, Hans Laser, Ralf Lichtinghagen, Hans Worthmann, Karin Weissenborn, Hannelore Ehrenreich

10.1016/j.bbih.2022.100494
2022-08-04

Teller J, Jung C, Wilke JBH, Schimmelpfennig SD, Hindermann M, Hinken L, Gabriel MM, Fegbeutel C, Schäfer A, Laser H, Lichtinghagen R, Worthmann H, Weissenborn K, Ehrenreich H

Abstract

kein Abstract verfügbar

Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically - transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as 'immunoprecipitator' of autoantibodies against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB). We thus hypothesized that during human anesthesia, pre-existing NMDAR1-AB will specifically bind to brain. Screening of N = 270 subjects undergoing general anesthesia during cardiac surgery for serum NMDAR1-AB revealed N = 25 NMDAR1-AB seropositives. Only N = 14 remained positive post-surgery. No changes in albumin, thyroglobulin or CRP were associated with reduction of serum NMDAR1-AB. Thus, upon anesthesia, BBB opening likely occurs also in humans.

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https://pubmed.ncbi.nlm.nih.gov/35965838/
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Keywords

BBB breakdown, Blood-brain-barrier opening, Cardiac surgery, Heart disease, Immunoglobulin class, Seroprevalence, Serum proteins.

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